Cannabis may dampen the strength or emotional impact of traumatic memories through synergistic mechanisms might make it easier for people with PTSD to rest or sleep and to feel less anxious and less involved with flashback memories.

The presence of endocannabinoid signaling systems within stress-sensitive nuclei of the hypothalamus, as well as upstream limbic structures (amygdala), point to the significance of this system for the regulation of neuroendocrine and behavioral responses to stress. Evidence is increasingly accumulating showing cannabinoids might play a role in fear extinction and anti-depressive effects (Passie, Torsten, Hinderk M. Emrich, and colleagues).

There is scientific evidence that shows there is a defect in the endocannabinoid system of those with PTSD.

Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the World Trade Center attacks.

Endocannabinoid (eCB) signaling has been identified as a modulator of adaptation to stress, and is integral to basal and stress-induced glucocorticoid regulation. Continue to Study

NextGen Brain Microdialysis: Applying Modern Metabolomics Technology to the Analysis of Extracellular Fluid in the Central Nervous System.

Microdialysis is a powerful method for in vivo neurochemical analyses. It allows fluid sampling in a dynamic manner in specific brain regions over an extended period of time. A particular focus has been the neurochemical analysis of extracellular fluids to explore central nervous system functions. Continue to Study

Metabolite profiling in posttraumatic stress disorder.

Traumatic stress does not only increase the risk for posttraumatic stress disorder (PTSD), but is also associated with adverse secondary physical health outcomes. Despite increasing efforts, we only begin to understand the underlying biomolecular processes. The hypothesis-free assessment of a wide range of metabolites (termed metabolite profiling) might contribute to the discovery of biological pathways underlying PTSD. Continue to Study

Central anandamide deficiency predicts stress- induced anxiety: behavioral reversal through endocannabinoid augmentation.

Stress is a major risk factor for the development of mood and anxiety disorders; elucidation of novel approaches to mitigate the deleterious effects of stress could have broad clinical applications. Pharmacological augmentation of central endogenous cannabinoid (eCB) signaling may be an effective therapeutic strategy to mitigate the adverse behavioral and physiological consequences of stress. Continue to Study